Recent Publications

2020

Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema. Sibony PA, Kupersmith MJ, Kardon RH. J Neuroophthalmol. 2020 Sep 4. doi: 10.1097/WNO.0000000000001078. Online ahead of print. PMID: 32909979

Oculomotor Nerve Palsy Due to Unusual Causes. Tian G, Kardon R, Feng C, Hong R, Sha Y, Sun X, Wang M. J Neuroophthalmol. 2020 Aug 19. doi: 10.1097/WNO.0000000000001032. Online ahead of print. PMID: 32833860

Focus on Data: Statistical Significance, Effect Size and the Accumulation of Evidence Achieved by Combining Study Results Through Meta-analysis. Ledolter J, Kardon RH. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):32. doi: 10.1167/iovs.61.10.32. PMID: 32797201 

Photophobia: shared pathophysiology underlying dry eye disease, migraine and traumatic brain injury leading to central neuroplasticity of the trigeminothalamic pathway. Diel RJ, Mehra D, Kardon R, Buse DC, Moulton E, Galor A. Br J Ophthalmol. 2020 Jul 23:bjophthalmol-2020-316417. doi: 10.1136/bjophthalmol-2020-316417. Online ahead of print.

Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis. Gramlich OW, Brown AJ, Godwin CR, Chimenti MS, Boland LK, Ankrum JA, Kardon RH. Transl Vis Sci Technol. 2020 Jul 10;9(8):16. doi: 10.1167/tvst.9.8.16. eCollection 2020 Jul. PMID: 32855863 

Parametric Statistical Inference for Comparing Means and Variances. Ledolter J, Gramlich OW, Kardon RH. Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):25. doi: 10.1167/iovs.61.8.25. PMID: 32692838 

Focus on Data: Statistical Design of Experiments and Sample Size Selection Using Power Analysis. Ledolter J, Kardon RH. Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):11. doi: 10.1167/iovs.61.8.11. PMID: 32645134 

Display of Data. Ledolter J, Gramlich OW, Kardon RH. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):25. doi: 10.1167/iovs.61.6.25. PMID: 32531059 

Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults. Holwerda SW, Kardon RH, Hashimoto R, Full JM, Nellis JK, DuBose LE, Fiedorowicz JG, Pierce GL .J Appl Physiol (1985). 2020 Jul 1;129(1):84-93. doi: 10.1152/japplphysiol.00252.2020. Epub 2020 May 21. PMID: 32437246

A Deep-Learning Approach for Automated OCT En-Face Retinal Vessel Segmentation in Cases of Optic Disc Swelling Using Multiple En-Face Images as Input. Islam MS, Wang JK, Johnson SS, Thurtell MJ, Kardon RH, Garvin MK. Transl Vis Sci Technol. 2020 Mar 24;9(2):17. doi: 10.1167/tvst.9.2.17. eCollection 2020 Mar. PMID: 32821471 

2019

The Tadpole Pupil: Case Series With Review of the Literature and New Considerations. Udry M, Kardon RH, Sadun F, Kawasaki A. Front Neurol. 2019 Aug 19;10:846. doi: 10.3389/fneur.2019.00846. eCollection 2019. PMID: 31481920 

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Harper MM, Hedberg-Buenz A, Herlein J, Abrahamson EE, Anderson MG, Kuehn MH, Kardon RH, Poolman P, Ikonomovic MD. Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2716-2725. doi: 10.1167/iovs.18-26353 .PMID: 31247112 

Threshold Static Automated Perimetry of the Full Visual Field in Idiopathic Intracranial Hypertension. Wall M, Subramani A, Chong LX, Galindo R, Turpin A, Kardon RH, Thurtell MJ, Bailey JA, Marin-Franch I. Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1898-1905. doi: 10.1167/iovs.18-26252. PMID: 31042797

Standards in Pupillography. Kelbsch C, Strasser T, Chen Y, Feigl B, Gamlin PD, Kardon R, Peters T, Roecklein KA, Steinhauer SR, Szabadi E, Zele AJ, Wilhelm H, Wilhelm BJ. Front Neurol. 2019 Feb 22;10:129. doi: 10.3389/fneur.2019.00129. eCollection 2019. PMID: 30853933 

Buzzing Sympathetic Nerves: A New Test to Enhance Anisocoria in Horner's Syndrome. Omary R, Bockisch CJ, Landau K, Kardon RH, Weber KP. Front Neurol. 2019 Feb 21;10:107. doi: 10.3389/fneur.2019.00107. eCollection 2019. PMID: 30846965 

Optical coherence tomography is highly sensitive in detecting prior optic neuritis. Xu SC, Kardon RH, Leavitt JA, Flanagan EP, Pittock SJ, Chen JJ. Neurology. 2019 Feb 5;92(6):e527-e535. doi: 10.1212/WNL.0000000000006873. Epub 2019 Jan 23 .PMID: 30674600 

2018

Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine. Rea BJ, Wattiez AS, Waite JS, Castonguay WC, Schmidt CM, Fairbanks AM, Robertson BR, Brown CJ, Mason BN, Moldovan-Loomis MC, Garcia-Martinez LF, Poolman P, Ledolter J, Kardon RH, Sowers LP, Russo AF. Pain. 2018 Nov;159(11):2306-2317. doi: 10.1097/j.pain.0000000000001337. PMID: 29994995 

Assessing Trends in Functional and Structural Characteristics: A Survey of Statistical Methods With an Example From Ophthalmology. Ledolter J, Kardon RH.Transl Vis Sci Technol. 2018 Oct 31;7(5):34. doi: 10.1167/tvst.7.5.34. eCollection 2018 Sep. PMID: 30402341 

Identification and treatment of the visual processing asymmetry in MS patients with optic neuritis: The Pulfrich phenomenon. Sobhanian MJ, Agarwal R, Meltzer E, Kildebeck E, Frohman BS, Frohman AN, Galetta SL, Saidha S, White O, Villoslada P, Paul F, Petzold A, Rennaker RL, Martinez-Lapiscina EH, Balcer LJ, Kardon R, Frohman EM, Frohman TC. J Neurol Sci. 2018 Apr 15;387:60-69. doi: 10.1016/j.jns.2018.01.029. Epub 2018 Feb 3. PMID: 29571874

Decreased retinal sensitivity in depressive disorder: a controlled study. Berman G, Muttuvelu D, Berman D, Larsen JI, Licht RW, Ledolter J, Kardon RH.Acta Psychiatr Scand. 2018 Mar;137(3):231-240. doi: 10.1111/acps.12851. Epub 2018 Jan 15. PMID: 29336011

Visual Fixation Instability in Multiple Sclerosis Measured Using SLO-OCT. Mallery RM, Poolman P, Thurtell MJ, Full JM, Ledolter J, Kimbrough D, Frohman EM, Frohman TC, Kardon RH. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):196-201. doi: 10.1167/iovs.17-22391. PMID: 29340646

Upper Eyelid Response to Topical 0.5% Apraclonidine. Kirkpatrick CA, Shriver EM, Clark TJE, Kardon RH. Ophthalmic Plast Reconstr Surg. 2018 Jan/Feb;34(1):13-19. doi: 10.1097/IOP.0000000000000843. PMID: 27984360

Identification of Herpes Zoster-Associated Temporal Arteritis Among Cases of Giant Cell Arteritis. Buckingham EM, Foley MA, Grose C, Syed NA, Smith ME, Margolis TP, Thurtell MJ, Kardon R. Am J Ophthalmol. 2018 Mar;187:51-60. doi: 10.1016/j.ajo.2017.12.017. Epub 2017 Dec 30. PMID: 29294312 

Unilateral periodic pupillary constriction causing alternating anisocoria. Conrad EC, Jivraj I, Kardon R, Liu GT. Neurology. 2018 Jan 9;90(2):86-88. doi: 10.1212/WNL.0000000000004809. Epub 2017 Dec 8. PMID: 29222127 

2017

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis. Petzold A, Balcer LJ, Calabresi PA, Costello F, Frohman TC, Frohman EM, Martinez-Lapiscina EH, Green AJ, Kardon R, Outteryck O, Paul F, Schippling S, Vermersch P, Villoslada P, Balk LJ; ERN-EYE IMSVISUAL. Lancet Neurol. 2017 Oct;16(10):797-812. doi: 10.1016/S1474-4422(17)30278-8. Epub 2017 Sep 12. PMID: 28920886 

Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril. Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Kardon RH, Yorek MA. Cornea. 2017 Jun;36(6):725-731. doi: 10.1097/ICO.0000000000001182. PMID: 28476051 

Peripapillary Retinal Pigment Epithelium Layer Shape Changes From Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial. Wang JK, Kardon RH, Ledolter J, Sibony PA, Kupersmith MJ, Garvin MK; OCT Sub-Study Committee and the NORDIC Idiopathic Intracranial Hypertension Study Group. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2554-2565. doi: 10.1167/iovs.16-21089. PMID: 28492874 

Does Testing More Frequently Shorten the Time to Detect Disease Progression? Ledolter J, Kardon RH. Transl Vis Sci Technol. 2017 May 1;6(3):1. doi: 10.1167/tvst.6.3.1. eCollection 2017 May. PMID: 28473945 

Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics: A Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis. Meltzer E, Sguigna PV, Subei A, Beh S, Kildebeck E, Conger D, Conger A, Lucero M, Frohman BS, Frohman AN, Saidha S, Galetta S, Calabresi PA, Rennaker R, Frohman TC, Kardon RH, Balcer LJ, Frohman EM. JAMA Neurol. 2017 May 1;74(5):574-582. doi: 10.1001/jamaneurol.2016.5131. PMID: 28135360

The Yield of Diagnostic Imaging in Patients with Isolated Horner Syndrome. Beebe JD, Kardon RH, Thurtell MJ. Neurol Clin. 2017 Feb;35(1):145-151. doi: 10.1016/j.ncl.2016.08.005. PMID: 27886891 

Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies. Chen JJ, AbouChehade JE, Iezzi R Jr, Leavitt JA, Kardon RH. Neuroophthalmology. 2017 Jan 27;41(2):76-83. doi: 10.1080/01658107.2016.1275703. eCollection 2017 Apr. PMID: 28348629 

Assessment of Rod, Cone, and Intrinsically Photosensitive Retinal Ganglion Cell Contributions to the Canine Chromatic Pupillary Response. Yeh CY, Koehl KL, Harman CD, Iwabe S, Guzman JM, Petersen-Jones SM, Kardon RH, Komáromy AM. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):65-78. doi: 10.1167/iovs.16-19865. PMID: 28061512 

Brain Injury Impact on the Eye and Vision. Barker F, Cockerham G, Goodrich G, Hartwick A, Kardon R, Mick AB, Swanson M. Optom Vis Sci. 2017 Jan;94(1):4-6. doi: 10.1097/OPX.0000000000001001. PMID: 28009763

The Effect of Treatment of Idiopathic Intracranial Hypertension on Prevalence of Retinal and Choroidal Folds. Kupersmith MJ, Sibony PA, Feldon SE, Wang JK, Garvin M, Kardon R; OCT Sub-Study Group for the NORDIC Idiopathic Intracranial Hypertension Treatment Trial. Am J Ophthalmol. 2017 Apr;176:77-86. doi: 10.1016/j.ajo.2016.12.017. Epub 2016 Dec 28. PMID: 28040526 

Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints. Yorek MS, Obrosov A, Shevalye H, Coppey LJ, Kardon RH, Yorek MA. Neuropharmacology. 2017 Apr;116:122-131. doi: 10.1016/j.neuropharm.2016.12.022. Epub 2016 Dec 23. PMID: 28025096 

2016

Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer. Chen JJ, Kardon RH. J Neuroophthalmol. 2016 Dec;36(4):417-438. doi: 10.1097/WNO.0000000000000422. PMID: 27636747

Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice. Yorek MS, Obrosov A, Lu B, Gerard C, Kardon RH, Yorek MA. J Neuropathol Exp Neurol. 2016 Nov 1;75(11):1072-1080. doi: 10.1093/jnen/nlw083. PMID: 27634964

Pupillary response abnormalities in depressive disorders. Laurenzo SA, Kardon R, Ledolter J, Poolman P, Schumacher AM, Potash JB, Full JM, Rice O, Ketcham A, Starkey C, Fiedorowicz JG. Psychiatry Res. 2016 Dec 30;246:492-499. doi: 10.1016/j.psychres.2016.10.039. Epub 2016 Oct 21. PMID: 27821359 

The Pattern of Visual Fixation Eccentricity and Instability in Optic Neuropathy and Its Spatial Relationship to Retinal Ganglion Cell Layer Thickness. Mallery RM, Poolman P, Thurtell MJ, Wang JK, Garvin MK, Ledolter J, Kardon RH. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT429-37. doi: 10.1167/iovs.15-18916. PMID: 27409502 

Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy. Kupersmith MJ, Garvin MK, Wang JK, Durbin M, Kardon R. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3588-93. doi: 10.1167/iovs.15-18736. PMID: 27388052 

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice. Trammell SA, Weidemann BJ, Chadda A, Yorek MS, Holmes A, Coppey LJ, Obrosov A, Kardon RH, Yorek MA, Brenner C .Sci Rep. 2016 May 27;6:26933. doi: 10.1038/srep26933. PMID: 27230286 

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response. Kostic C, Crippa SV, Martin C, Kardon RH, Biel M, Arsenijevic Y, Kawasaki A. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2501-8. doi: 10.1167/iovs.16-19150. PMID: 27152964

Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy. Yorek MS, Davidson EP, Poolman P, Coppey LJ, Obrosov A, Holmes A, Kardon RH, Yorek MA. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2412-9. doi: 10.1167/iovs.16-19435. PMID: 27145474 

Deficits in Visual System Functional Connectivity after Blast-Related Mild TBI are Associated with Injury Severity and Executive Dysfunction. Gilmore CS, Camchong J, Davenport ND, Nelson NW, Kardon RH, Lim KO, Sponheim SR. Brain Behav. 2016 Mar 23;6(5):e00454. doi: 10.1002/brb3.454. eCollection 2016 May. PMID: 27257516 

Visual Field Outcomes for the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) Wall M, Johnson CA, Cello KE, Zamba KD, McDermott MP, Keltner JL; NORDIC Idiopathic Intracranial Hypertension Study Group. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):805-12. doi: 10.1167/iovs.15-18626. PMID: 26934136 

Author Response: Choroidal Folds in Astronauts. Sibony PA, Kupersmith MJ, Feldon SE, Kardon R. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):593. doi: 10.1167/iovs.15-18927. PMID: 26886893 

Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints. Yorek MS, Coppey LJ, Shevalye H, Obrosov A, Kardon RH, Yorek MA. J Nutr Metab. 2016;2016:5905891. doi: 10.1155/2016/5905891. Epub 2016 Sep 28. PMID: 27774316